Article
Mutagenicity of vinyl chloride and its reactive metabolites, chloroethylene oxide and chloroacetaldehyde, in a metabolically competent human B-lymphoblastoid line.
Carcinogenesis - 1 Jan 1997
Chiang S Y, Swenberg J A, Weisman W H, Skopek T R
Abstract excerpt
Vinyl chloride (VC), a known human and rodent carcinogen, is metabolically activated by cytochrome P450 to chloroethylene oxide (CEO), which can rearrange to chloroacetaldehyde (CAA) or undergo hydrolysis. To further understand the roles of CEO and CAA in VC mutagenesis, the types and frequencies...
Topics
- Acetaldehyde
- B-Lymphocytes
- Cell Line
- Dose-Response Relationship, Drug
- Ethylene Oxide
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Mutagenicity Tests
- Mutation
- Time Factors
- Vinyl Chloride