Article
Factors affecting HPRT mutant frequency in T-lymphocytes of smokers and nonsmokers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2000
Jones I M, Moore D H, Thomas C B, Thompson C L, Strout C L, Burkhart-Schultz K
Abstract excerpt
The frequency of thioguanine-resistant, hypoxanthine phosphoribosyltransferase-deficient lymphocytes in the peripheral blood of human subjects was used to study the genotoxic effects of smoking. Sixty-two nonsmokers and 58 smokers, aged 19 to 45 years with average ages of 30 and 32 years, respect...
Topics
- Adult
- Age Factors
- Analysis of Variance
- Bias
- Female
- Gene Frequency
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Likelihood Functions
- Male
- Middle Aged
- Mutation
- Predictive Value of Tests
- Smoking
- T-Lymphocytes
- Time Factors