Article
Sulfotransferases: genetics and role in toxicology.
Toxicology letters - 15 Mar 2000
Glatt H, Engelke C E, Pabel U, Teubner W, Jones A L, Coughtrie M W, Andrae U, Falany C N, Meinl W
Abstract excerpt
The mammalian xenobiotic-metabolizing sulfotransferases are cytosolic enzymes, which form a gene superfamily (SULT). Ten distinct human SULT forms are known. Two SULT forms represent splice variants, the other forms are encoded by separate genes. Common functional polymorphisms of the transcribed region are known for two of the forms. We have expressed 16 separate rat and human SULTs as well as some of their...
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