Influence of GSTM1 genotype on sister chromatid exchange induction by styrene-7,8-oxide and 1,2-epoxy-3-butene in cultured human lymphocytes.

doi:10.1093/carcin/16.4.947

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Article

Influence of GSTM1 genotype on sister chromatid exchange induction by styrene-7,8-oxide and 1,2-epoxy-3-butene in cultured human lymphocytes.

Carcinogenesis - 1 Apr 1995

Uusküla M, Järventaus H, Hirvonen A, Sorsa M, Norppa H

Abstract excerpt

Glutathione S-transferase M1 (GSTM1), catalyzing the conjugation of various reactive molecules with glutathione (GSH), shows genetic polymorphism in humans. Almost half of all Caucasians lack the GSTM1 gene, being theoretically at a higher risk from the toxic effects of substrates for GSTM1. The...

Topics

Adult
Cells, Cultured
Epoxy Compounds
Female
Gene Expression
Genotype
Glutathione Transferase
Humans
Isoenzymes
Kinetics
Lymphocytes
Male
Middle Aged
Mutagens
Sister Chromatid Exchange

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