Article
Impact of sampling time on the detection of mutations in rapidly proliferating tissues using transgenic rodent gene mutation models: A review.
Environmental and molecular mutagenesis - 1 Dec 2022
Douglas George R, Beevers Carol, Gollapudi Bhaskar, Keig-Shevlin Zena, Kirkland David, O'Brien Jason M, van Benthem Jan, Yauk Carole L, Young Robert R, Marchetti Francesco
Abstract excerpt
The OECD Test Guideline 488 (TG 488) for the Transgenic Rodent Gene Mutation Assay has undergone several revisions to update the recommended design for studying mutations in somatic tissues and male germ cells. The recently revised TG recommends a single sampling time of 28 days following 28 days of exposure (i.e., 28 + 28 days) for all tissues, irrespective of proliferation rates. An alternative design (i.e.,...
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