Protective efficacy of hGSTM1-1 against B[a]P and (+)- or (-)-B[a]P-7,8-dihydrodiol cytotoxicity, mutagenicity, and macromolecular adducts in V79 cells coexpressing hCYP1A1.

doi:10.1093/toxsci/kfm133

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Article

Protective efficacy of hGSTM1-1 against B[a]P and (+)- or (-)-B[a]P-7,8-dihydrodiol cytotoxicity, mutagenicity, and macromolecular adducts in V79 cells coexpressing hCYP1A1.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Sept 2007

Kushman Mary E, Kabler Sandra L, Ahmad Sarfaraz, Doehmer Johannes, Morrow Charles S, Townsend Alan J

Abstract excerpt

Transgenic cell lines were constructed to study the dynamics of competition between activation versus detoxification of benzo[a]pyrene (B[a]P) or B[a]P-7,8-dihydrodiol metabolites. Stably transfected V79MZ cells expressing human cytochrome P4501A1 (hCYP1A1) alone or in combination with human glutathione-S-transferase M1 (hGSTM1) were used to determine how effectively this GST isozyme protects against cytotoxic,...

Topics

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Animals
Benzo(a)pyrene
Cell Line
Cricetinae
Cricetulus
Cytochrome P-450 CYP1A1
DNA
DNA Adducts
Dihydroxydihydrobenzopyrenes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fibroblasts

Gene Expression Regulation, Enzymologic

Glutathione Transferase

Humans

Hypoxanthine Phosphoribosyltransferase

Inactivation, Metabolic

Mutagenicity Tests

Mutagens

Source

Open in PubMed

Identifiers

PMID: 17525473
DOI: 10.1093/toxsci/kfm133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17525473-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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