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Article

Effect of allelic heterogeneity on the power of the transmission disequilibrium test.

Genetic epidemiology - 1 Feb 2000

Slager S L, Huang J, Vieland V J

Abstract excerpt

Due in part to an influential paper by Risch and Merikangas [(1996) Science 273:1516-1517], which suggested that disequilibrium tests would have greater power to detect genes of small effect than would linkage tests, interest in the use of the Transmission Disequilibrium Test (TDT) as an analysis tool for genomewide studies is steadily growing. However, the paper by Risch and Merikangas made several simplifying...

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PMID: 10642427
DOI: 10.1002/(SICI)1098-2272(200002)18:2<143::AID-GEPI4>3.0.CO;2-5

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Source receipt: pubmed, retrieved 7 Sept 2026.

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