Increased efficiency of case-control association analysis by using allele-sharing and covariate information.

doi:10.1159/000109732

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Increased efficiency of case-control association analysis by using allele-sharing and covariate information.

Human heredity - 1 Jan 2008

Schmidt Silke, Schmidt Michael A, Qin Xuejun, Martin Eden R, Hauser Elizabeth R

Abstract excerpt

OBJECTIVE: We compared the efficiency of case selection strategies for following up a genome-wide linkage screen of multiplex families. We simulated datasets under three models by which continuous environmental or clinical covariates may contribute to disease risk or linkage heterogeneity: (i) a quantitative trait locus (QTL) underlying a continuous disease risk factor, (ii) a gene-environment interaction model,...

Topics

Analysis of Variance
Case-Control Studies
Gene Frequency
Genetic Linkage
Genetic Predisposition to Disease
Genotype
Humans
Models, Genetic
Models, Statistical
Quantitative Trait Loci
Siblings

Source

Open in PubMed Open full text

Identifiers

PMID: 17934318
DOI: 10.1159/000109732
PMCID: PMC2709298

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics