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Article

Increased efficiency of case-control association analysis by using allele-sharing and covariate information.

Human heredity - 1 Jan 2008

Schmidt Silke, Schmidt Michael A, Qin Xuejun, Martin Eden R, Hauser Elizabeth R

Abstract excerpt

OBJECTIVE: We compared the efficiency of case selection strategies for following up a genome-wide linkage screen of multiplex families. We simulated datasets under three models by which continuous environmental or clinical covariates may contribute to disease risk or linkage heterogeneity: (i) a quantitative trait locus (QTL) underlying a continuous disease risk factor, (ii) a gene-environment interaction model,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17934318
DOI: 10.1159/000109732
PMCID: PMC2709298

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NPL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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