Haplotype sharing correlation analysis using family data: a comparison with family-based association test in the presence of allelic heterogeneity.

doi:10.1002/gepi.20005

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Article

Haplotype sharing correlation analysis using family data: a comparison with family-based association test in the presence of allelic heterogeneity.

Genetic epidemiology - 1 Jul 2004

Qian Dajun

Abstract excerpt

The haplotype-sharing correlation (HSC) method for association analysis using family data is revisited by introducing a permutation procedure for estimating region-wise significance at each marker on a study segment. In simulation studies, the HSC method has a correct type 1 error rate in both unstructured and structured populations. The HSC signals on disease segments occur in the vicinity of a true disease...

Topics

Alleles
Chromosome Mapping
Computer Simulation
Genetic Heterogeneity
Genotype
Haplotypes
Humans
Linkage Disequilibrium
Models, Genetic
Models, Statistical
Nuclear Family
Pedigree
Phenotype
Sensitivity and Specificity
Software

Source

Open in PubMed

Identifiers

PMID: 15185402
DOI: 10.1002/gepi.20005

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