Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterogeneity in IBD allele sharing among covariate-defined subgroups: issues and findings for affected relatives.

Human heredity - 1 Jan 2003

Bull Shelley B, Mirea Lucia, Briollais Laurent, Logan Alexander G

Abstract excerpt

OBJECTIVES: Modelling of variation in identical-by-descent (IBD) allele sharing using covariates can increase power to detect linkage, identify covariate-defined subgroups linked to particular marker regions, and improve the design of subsequent studies to localize genes and characterize their effects. In this report, we highlight issues that arise in studies of families with affected relatives. METHODS: Mirea et...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Analysis of Variance
Share to Computer Simulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Recessive

Share to Genetic Heterogeneity

Share to Genetic Linkage

Share to Genetic Predisposition to Disease

Share to Hypertension

Source

Identifiers

PMID: 14614243
DOI: 10.1159/000073737

Genes

NPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterogeneity in IBD allele sharing among covariate-defined subgroups: issues and findings for affected relatives.PMID 14614243Read ↗

Tests for covariate-associated heterogeneity in IBD allele sharing of affected relatives.Semantic proximity Read ↗

Assessing whether an allele can account in part for a linkage signal: the Genotype-IBD Sharing Test (GIST).Semantic proximity Read ↗

Analysis of affected sib pairs, with covariates--with and without constraints.Semantic proximity Read ↗

Increased efficiency of case-control association analysis by using allele-sharing and covariate information.Semantic proximity Read ↗

Genome-wide identity-by-descent sharing among CEPH siblings.Semantic proximity Read ↗

Potential bias in Generalized Estimating Equations linkage methods under incomplete information.Semantic proximity Read ↗

Incorporation of covariates in simultaneous localization of two linked loci using affected relative pairs.Semantic proximity Read ↗

Interpreting analyses of continuous covariates in affected sibling pair linkage studies.Semantic proximity Read ↗

Incorporating covariates in mapping heterogeneous traits: a hierarchical model using empirical Bayes estimation.Semantic proximity Read ↗

Appropriate use of information on family history of disease in recruitment for linkage analysis studies.Semantic proximity Read ↗

Allele-sharing among affected relatives: non-parametric methods for identifying genes.Semantic proximity Read ↗

The bias introduced by population stratification in IBD based linkage analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.