Heterogeneity in IBD allele sharing among covariate-defined subgroups: issues and findings for affected relatives.

doi:10.1159/000073737

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Article

Heterogeneity in IBD allele sharing among covariate-defined subgroups: issues and findings for affected relatives.

Human heredity - 1 Jan 2003

Bull Shelley B, Mirea Lucia, Briollais Laurent, Logan Alexander G

Abstract excerpt

OBJECTIVES: Modelling of variation in identical-by-descent (IBD) allele sharing using covariates can increase power to detect linkage, identify covariate-defined subgroups linked to particular marker regions, and improve the design of subsequent studies to localize genes and characterize their ef...

Topics

Alleles
Analysis of Variance
Computer Simulation
Data Interpretation, Statistical
Genes, Recessive
Genetic Heterogeneity
Genetic Linkage
Genetic Predisposition to Disease
Humans
Hypertension

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