Article
Allele-sharing among affected relatives: non-parametric methods for identifying genes.
Statistical methods in medical research - 1 Feb 2001
Shih M C, Whittemore A S
Abstract excerpt
Non-parametric linkage analysis examines similarities among affected relatives in alleles of one or more genetic markers (pieces of DNA at known locations on a chromosome). The objective is to evaluate departures from the null hypothesis that the markers are not near a disease gene. Under the null hypothesis, Mendel's laws give the probabilities that a set of relatives exhibits a particular allele-sharing...
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