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Article

U4 small nuclear RNA can function in both the major and minor spliceosomes.

Proceedings of the National Academy of Sciences of the United States of America - 6 Jan 2004

Shukla Girish C, Padgett Richard A

Abstract excerpt

U4 small nuclear RNA (snRNA) and U6 snRNA form a base-paired di-snRNP complex that is essential for pre-mRNA splicing of the major class of metazoan nuclear introns. The functionally analogous but highly diverged U4atac and U6atac snRNAs form a similar complex that is involved in splicing of the minor class of introns. Previous results with mutants of U6atac in which a substructure was replaced by the analogous...

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Identifiers

PMID: 14691257
DOI: 10.1073/pnas.0304919101
PMCID: PMC314144

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Source receipt: pubmed, retrieved 7 Sept 2026.

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U4 small nuclear RNA can function in both the major and minor spliceosomes.PMID 14691257Read ↗

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Domains of human U4atac snRNA required for U12-dependent splicing in vivo.Semantic proximity Read ↗

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