Article
U4 small nuclear RNA can function in both the major and minor spliceosomes.
Proceedings of the National Academy of Sciences of the United States of America - 6 Jan 2004
Shukla Girish C, Padgett Richard A
Abstract excerpt
U4 small nuclear RNA (snRNA) and U6 snRNA form a base-paired di-snRNP complex that is essential for pre-mRNA splicing of the major class of metazoan nuclear introns. The functionally analogous but highly diverged U4atac and U6atac snRNAs form a similar complex that is involved in splicing of the minor class of introns. Previous results with mutants of U6atac in which a substructure was replaced by the analogous...
Topics
- Arabidopsis
- Base Sequence
- Humans
- In Vitro Techniques
- Introns
- Models, Molecular
- Mutation
- Nucleic Acid Conformation
- RNA
- RNA Splicing
- RNA, Plant
- RNA, Small Nuclear
- Spliceosomes