U1 small nuclear ribonucleoprotein and splicing inhibition by the rous sarcoma virus negative regulator of splicing element.

doi:10.1128/JVI.73.3.2385-2393.1999

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Article

U1 small nuclear ribonucleoprotein and splicing inhibition by the rous sarcoma virus negative regulator of splicing element.

Journal of virology - 1 Mar 1999

McNally L M, McNally M T

Abstract excerpt

Retroviruses require both spliced and unspliced RNA for replication. Accumulation of unspliced Rous sarcoma virus RNA is facilitated in part by a negative cis element in the gag region, termed the negative regulator of splicing (NRS), which serves to repress splicing of viral RNA but can also blo...

Topics

Avian Sarcoma Viruses
Binding Sites
Genes, Viral
Mutation
RNA Splicing
Ribonucleoprotein, U1 Small Nuclear
Virus Assembly

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