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Article

U1 small nuclear ribonucleoprotein and splicing inhibition by the rous sarcoma virus negative regulator of splicing element.

Journal of virology - 1 Mar 1999

McNally L M, McNally M T

Abstract excerpt

Retroviruses require both spliced and unspliced RNA for replication. Accumulation of unspliced Rous sarcoma virus RNA is facilitated in part by a negative cis element in the gag region, termed the negative regulator of splicing (NRS), which serves to repress splicing of viral RNA but can also block splicing of heterologous introns. The NRS binds components of the splicing machinery including SR proteins, U1 and...

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Identifiers

PMID: 9971822
DOI: 10.1128/JVI.73.3.2385-2393.1999
PMCID: PMC104484

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Source receipt: pubmed, retrieved 7 Sept 2026.

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