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Article

Protein-free spliceosomal snRNAs catalyze a reaction that resembles the first step of splicing.

RNA (New York, N.Y.) - 1 Dec 2007

Valadkhan Saba, Mohammadi Afshin, Wachtel Chaim, Manley James L

Abstract excerpt

Splicing of introns from mRNA precursors is a two-step reaction performed by the spliceosome, an immense cellular machine consisting of over 200 different proteins and five small RNAs (snRNAs). We previously demonstrated that fragments of two of these RNAs, U6 and U2, can catalyze by themselves a splicing-related reaction, involving one of the two substrates of the first step of splicing, the branch site...

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Source

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Identifiers

PMID: 17940139
DOI: 10.1261/rna.626207
PMCID: PMC2080592

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Protein-free spliceosomal snRNAs catalyze a reaction that resembles the first step of splicing.PMID 17940139Read ↗

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