U6 snRNA function in nuclear pre-mRNA splicing: a phosphorothioate interference analysis of the U6 phosphate backbone.

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Article

U6 snRNA function in nuclear pre-mRNA splicing: a phosphorothioate interference analysis of the U6 phosphate backbone.

RNA (New York, N.Y.) - 1 Mar 1995

Yu Y T, Maroney P A, Darzynkiwicz E, Nilsen T W

Abstract excerpt

U6 snRNA is essential for and may participate in the catalysis of pre-mRNA splicing. Extensive mutational analyses in several systems have identified nucleotides essential for U6 function in splicing; however, relatively little is known regarding the role of the U6 phosphate backbone. We previous...

Topics

Animals
Ascaris lumbricoides
Base Sequence
Cell Nucleus
Models, Genetic
Molecular Sequence Data
Mutation
RNA Precursors
RNA Splicing
RNA, Catalytic
RNA, Messenger
RNA, Small Nuclear
Spliceosomes
Structure-Activity Relationship
Thionucleotides

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Identifiers

PMID: 7489488
PMCID: PMC1369059

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7489488-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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