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Article

Rearrangement of competing U2 RNA helices within the spliceosome promotes multiple steps in splicing.

Genes & development - 1 Apr 2007

Perriman Rhonda J, Ares Manuel

Abstract excerpt

Nuclear pre-messenger RNA (pre-mRNA) splicing requires multiple spliceosomal small nuclear RNA (snRNA) and pre-mRNA rearrangements. Here we reveal a new snRNA conformational switch in which successive roles for two competing U2 helices, stem IIa and stem IIc, promote distinct splicing steps. When stem IIa is stabilized by loss of stem IIc, rapid ATP-independent and Cus2p-insensitive prespliceosome formation...

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Identifiers

PMID: 17403781
DOI: 10.1101/gad.1524307
PMCID: PMC1838532

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Source receipt: pubmed, retrieved 7 Sept 2026.

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