Article
Requirement of U12 snRNA for in vivo splicing of a minor class of eukaryotic nuclear pre-mRNA introns.
Science (New York, N.Y.) - 22 Mar 1996
Hall S L, Padgett R A
Abstract excerpt
A conserved sequence element in a minor class of eukaryotic pre-messenger RNA (pre-mRNA) introns was previously proposed to base pair with a complementary sequence in the U12 small nuclear RNA (snRNA) in a manner analogous to the pairing of US snRNA with the branch site sequence of the major class of introns. Here, mutations generated in this conserved sequence element block the splicing of a member of this minor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.