Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A mutational analysis of U12-dependent splice site dinucleotides.

RNA (New York, N.Y.) - 1 Sept 2005

Dietrich Rosemary C, Fuller John D, Padgett Richard A

Abstract excerpt

Introns spliced by the U12-dependent minor spliceosome are divided into two classes based on their splice site dinucleotides. The /AU-AC/ class accounts for about one-third of U12-dependent introns in humans, while the /GU-AG/ class accounts for the other two-thirds. We have investigated the in vivo and in vitro splicing phenotypes of mutations in these dinucleotide sequences. A 5' A residue can splice to any 3'...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CHO Cells
Share to Cricetinae
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Introns

Share to RNA, Small Nuclear

Share to RNA Splicing

Share to Sequence Analysis, RNA

Share to Spliceosomes

Source

Open in PubMed Open full text

Identifiers

PMID: 16043500
DOI: 10.1261/rna.7206305
PMCID: PMC1370826

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mutational analysis of U12-dependent splice site dinucleotides.PMID 16043500Read ↗

Role of the 3' splice site in U12-dependent intron splicing.Semantic proximity Read ↗

Minor spliceosome and disease.Semantic proximity Read ↗

Mutational analysis of the U12-dependent branch site consensus sequence.Semantic proximity Read ↗

Functionally important structural elements of U12 snRNA.Semantic proximity Read ↗

Sequence contexts that determine the pathogenicity of base substitutions at position +3 of donor splice-sites.Semantic proximity Read ↗

Regulation of gene expression through inefficient splicing of U12-type introns.Semantic proximity Read ↗

U4 small nuclear RNA can function in both the major and minor spliceosomes.Semantic proximity Read ↗

Splice-mediated insertion of an Alu sequence inactivates ornithine delta-aminotransferase: a role for Alu elements in human mutation.Semantic proximity Read ↗

Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome.Semantic proximity Read ↗

Splice site requirements and switches in plants.Semantic proximity Read ↗

In vivo and In vitro methods to identify DNA sequence variants that alter RNA Splicing.Semantic proximity Read ↗

Base pairing with U6atac snRNA is required for 5' splice site activation of U12-dependent introns in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.