Article
Mice with transgenic overexpression of lipid phosphate phosphatase-1 display multiple organotypic deficits without alteration in circulating lysophosphatidate level.
Cellular signalling - 1 Mar 2004
Yue Junming, Yokoyama Kazuaki, Balazs Louisa, Baker Daniel L, Smalley David, Pilquil Carlos, Brindley David N, Tigyi Gabor
Abstract excerpt
Lipid phosphate phosphatase 1 (LPP-1) is presumed to regulate the balance between lipid phosphates and their dephosphorylated counterparts. The currently prevailing hypothesis based on in vitro studies proposes that LPP-1 should regulate phospholipid lipid growth factors and second messengers, including lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P), diacylglycerol (DAG), and phosphatidic acid (PA)....
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