Article
In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice.
Biochimica et biophysica acta - 23 May 2002
Yang Amy H, Ishii Isao, Chun Jerold
Abstract excerpt
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are extracellular ligands for a family of G protein-coupled receptors (GPCRs), LPA1/2/3 and S1P1/2/3/4/5. Through coupling to multiple classes of G proteins and activating multiple signaling pathways, LPA/S1P receptors have been shown to be integral players for many essential cellular and physiological processes. Generation and analysis of mice...
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