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Article

Portrait of PTEN: messages from mutant mice.

Cancer science - 1 Feb 2008

Suzuki Akira, Nakano Toru, Mak Tak Wah, Sasaki Takehiko

Abstract excerpt

PTEN is a tumor suppressor gene mutated in many human sporadic cancers and in hereditary cancer syndromes such as Cowden disease. The major substrate of PTEN is phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3), a second messenger molecule produced following PI3K activation induced by a vari...

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Source

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Identifiers

PMID: 18201277
DOI: 10.1111/j.1349-7006.2007.00670.x
PMCID: PMC11158684

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18201277-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Portrait of PTEN: messages from mutant mice.PMID 18201277Read ↗

PTEN: from pathology to biology.Semantic proximity Read ↗

The biology and clinical relevance of the PTEN tumor suppressor pathway.Semantic proximity Read ↗

Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressorSemantic proximity Read ↗

[Role of PTEN tumor suppressor gene in disease: PTEN-deficient mice].Semantic proximity Read ↗

Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function.Semantic proximity Read ↗

Modeling Cancer-Associated Mutations of PTEN in Mice.Semantic proximity Read ↗

The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities.Semantic proximity Read ↗

Tenets of PTEN tumor suppression.Semantic proximity Read ↗

Allele-specific tumor spectrum in pten knockin mice.Semantic proximity Read ↗

PTEN: tumour suppressor, multifunctional growth regulator and more.Semantic proximity Read ↗

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PTEN: Multiple Functions in Human Malignant TumorsSemantic proximity Read ↗

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