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Article

Phosphatidate phosphatase-1 is functionally conserved in lipid synthesis and storage from human to yeast.

Acta biologica Hungarica - 1 Dec 2014

Fang Zhijia, Wang Song, Du Xiuxiu, Shi Ping, Huang Zhiwei

Abstract excerpt

Phosphatidate phosphatase-1 (PAP1) enzymes (yeast Pah1p/Smp2p, mammalian lipin1-3) have a key role in lipid homeostasis by controlling the relative proportions of its substrate phosphatidate (PA) and its product diacylglycerol (DAG). Recent investigation shows that mammalian lipin-1 complements phenotypes exhibited by yeast pah1Δ mutant cells, which indicates the functions of PAP1 enzymes are evolutionarily...

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Source

Identifiers

PMID: 25475986
DOI: 10.1556/ABiol.65.2014.4.11

Genes

LPIN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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