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Article

Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jan 2013

Mitra Mayurranjan S, Chen Zhouji, Ren Hongmei, Harris Thurl E, Chambers Kari T, Hall Angela M, Nadra Karim, Klein Samuel, Chrast Roman, Su Xiong, Morris Andrew J, Finck Brian N

Abstract excerpt

Lipin 1 is a coregulator of DNA-bound transcription factors and a phosphatidic acid (PA) phosphatase (PAP) enzyme that catalyzes a critical step in the synthesis of glycerophospholipids. Lipin 1 is highly expressed in adipocytes, and constitutive loss of lipin 1 blocks adipocyte differentiation; however, the effects of Lpin1 deficiency in differentiated adipocytes are unknown. Here we report that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cyclic Nucleotide Phosphodiesterases, Type 4

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Identifiers

PMID: 23267081
DOI: 10.1073/pnas.1213493110
PMCID: PMC3545773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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