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Article

Liver-specific loss of lipin-1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic TG accumulation in mice.

Journal of lipid research - 1 Apr 2015

Schweitzer George G, Chen Zhouji, Gan Connie, McCommis Kyle S, Soufi Nisreen, Chrast Roman, Mitra Mayurranjan S, Yang Kui, Gross Richard W, Finck Brian N

Abstract excerpt

Lipin proteins (lipin 1, 2, and 3) regulate glycerolipid homeostasis by acting as phosphatidic acid phosphohydrolase (PAP) enzymes in the TG synthesis pathway and by regulating DNA-bound transcription factors to control gene transcription. Hepatic PAP activity could contribute to hepatic fat accumulation in response to physiological and pathophysiological stimuli. To examine the role of lipin 1 in regulating...

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Identifiers

PMID: 25722343
DOI: 10.1194/jlr.M055962
PMCID: PMC4373742

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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