Article
The phosphate transporter PiT1 (Slc20a1) revealed as a new essential gene for mouse liver development.
PloS one - 10 Feb 2010
Beck Laurent, Leroy Christine, Beck-Cormier Sarah, Forand Anne, Salaün Christine, Paris Nadine, Bernier Adeline, Ureña-Torres Pablo, Prié Dominique, Ollero Mario, Coulombel Laure, Friedlander Gérard
Abstract excerpt
BACKGROUND: PiT1 (or SLC20a1) encodes a widely expressed plasma membrane protein functioning as a high-affinity Na(+)-phosphate (Pi) cotransporter. As such, PiT1 is often considered as a ubiquitous supplier of Pi for cellular needs regardless of the lack of experimental data. Although the importance of PiT1 in mineralizing processes have been demonstrated in vitro in osteoblasts, chondrocytes and vascular smooth...
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