Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2010

Ohnishi Mutsuko, Razzaque M Shawkat

Abstract excerpt

Identifying factors that accelerate the aging process can provide important therapeutic targets for slowing down this process. Misregulation of phosphate homeostasis has been noted in various skeletal, cardiac, and renal diseases, but the exact role of phosphate toxicity in mammalian aging is not clearly defined. Phosphate is widely distributed in the body and is involved in cell signaling, energy metabolism,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Creatinine
Share to Glucuronidase
Share to In Situ Nick-End Labeling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intestinal Mucosa

Share to Intestines

Share to Klotho Proteins

Share to Phosphates

Source

Open in PubMed Open full text

Identifiers

PMID: 20418498
DOI: 10.1096/fj.09-152488
PMCID: PMC2923352

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging.PMID 20418498Read ↗

The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant mice.Semantic proximity Read ↗

Klotho and aging.Semantic proximity Read ↗

In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis.Semantic proximity Read ↗

Klotho and the aging process.Semantic proximity Read ↗

Klotho: a fundamental regulator of aging.Semantic proximity Read ↗

Hyperphosphatemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signalingSemantic proximity Read ↗

The Spectrum of Fundamental Basic Science Discoveries Contributing to Organismal AgingSemantic proximity Read ↗

Relationship of the bone phenotype of the Klotho mutant mouse model of accelerated aging to changes in skeletal architecture that occur with chronological aging.Semantic proximity Read ↗

Bicarbonate-sensitive calcification and lifespan of klotho-deficient mice.Semantic proximity Read ↗

Premature aging in klotho mutant mice: cause or consequence?Semantic proximity Read ↗

The Antisenescence Protein Klotho Is Necessary for FGF23-Induced PhosphaturiaSemantic proximity Read ↗

Skeletal phenotypes and molecular mechanisms in aging mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.