Article
PTEN: tumour suppressor, multifunctional growth regulator and more.
Human molecular genetics - 15 Oct 2003
Goberdhan Deborah C I, Wilson Clive
Abstract excerpt
The tumour suppressor gene PTEN is mutated in a wide range of human cancers at a frequency roughly comparable with p53. In addition, germline PTEN mutations are associated with several dominant growth disorders. The molecular and cellular basis of these disorders has been elucidated by detailed in vivo genetic analysis in model organisms, in particular the fruit fly and mouse. Studies in the fly have shown that...
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