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Article

Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells.

The Journal of biological chemistry - 26 Mar 2004

Audero Enrica, Cascone Ilaria, Maniero Fabrizio, Napione Lucia, Arese Marco, Lanfrancone Luisa, Bussolino Federico

Abstract excerpt

Angiopoietin-1 can promote migration, sprouting, and survival of endothelial cells through activation of different signaling pathways triggered by the Tie2 tyrosine kinase receptor. ShcA adapter proteins are targets of activated tyrosine kinases and are implicated in the transmission of activation signals to the Ras/mitogen-activated protein kinase pathway. Here we report the identification of an interaction...

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PMID: 14665640
DOI: 10.1074/jbc.M307456200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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