Article
Shb promotes blood vessel formation in embryoid bodies by augmenting vascular endothelial growth factor receptor-2 and platelet-derived growth factor receptor-beta signaling.
Experimental cell research - 15 Aug 2005
Rolny Charlotte, Lu Lingge, Agren Nina, Nilsson Ingrid, Roe Cheryl, Webb Gene C, Welsh Michael
Abstract excerpt
The mechanisms controlling blood vessel formation during early embryonal development have only partly been elucidated. Shb is an adaptor protein previously implicated in the angiogenic response to vascular endothelial growth factor (VEGF). To elucidate a possible role of Shb in embryonic vascular development, wild-type and SH2 domain mutated (R522K) Shb were overexpressed in murine embryonic stem (ES) cells....
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