Article
Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2002
Zanetti Adriana, Lampugnani Maria Grazia, Balconi Giovanna, Breviario Ferruccio, Corada Monica, Lanfrancone Luisa, Dejana Elisabetta
Abstract excerpt
Vascular endothelial (VE)-cadherin is endothelium specific, mediates homophilic adhesion, and is clustered at intercellular junctions. VE-cadherin is required for normal development of the vasculature in the embryo and for angiogenesis in the adult. Here, we report that VE-cadherin is associated with VE growth factor (VEGF) receptor-2 (VEGFR-2) on the exposure of endothelial cells to VEGF. The binding parallels...
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