Article
Identification of two focal adhesion targeting sequences in the adapter molecule p130(Cas).
Biochimica et biophysica acta - 11 Dec 2000
Harte M T, Macklem M, Weidow C L, Parsons J T, Bouton A H
Abstract excerpt
The adapter molecule CAS is localized primarily within focal adhesions in fibroblasts. Because many of the cellular functions attributed to CAS are likely to be dependent on its presence in focal adhesions, this study was undertaken to identify regions of the protein that are involved in its localization. The SH3 domain of CAS, when expressed in isolation from the rest of the protein, was able to target to focal...
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