Article
Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands.
Molecular cell - 12 Mar 2010
Seegar Tom C M, Eller Becca, Tzvetkova-Robev Dorothea, Kolev Momchil V, Henderson Scott C, Nikolov Dimitar B, Barton William A
Abstract excerpt
The Tie family of endothelial-specific receptor tyrosine kinases is essential for cell proliferation, migration, and survival during angiogenesis. Despite considerable similarity, experiments with Tie1- or Tie2-deficient mice highlight distinct functions for these receptors in vivo. The Tie2 receptor is further unique with respect to its structurally homologous ligands. Angiopoietin-2 and -3 can function as...
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