Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxic induction of the hypoxia-inducible factor is mediated via the adaptor protein Shc in endothelial cells.

Circulation research - 12 Jul 2002

Jung Frank, Haendeler Judith, Hoffmann Jörg, Reissner Agnes, Dernbach Elisabeth, Zeiher Andreas M, Dimmeler Stefanie

Abstract excerpt

Tyrosine kinase cascades may play a role in the hypoxic regulation of hypoxia-inducible factor (HIF)-1. We investigated the role of tyrosine kinase phosphorylation and of the Shc/Ras cascade on hypoxic HIF-1 stabilization. Exposure of human umbilical vein endothelial cells to hypoxia results in HIF protein stabilization as early as 10 minutes, with a maximum at 3 hours, and also in Shc tyrosine phosphorylation,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Hypoxia
Share to Cobalt

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cycloheximide

Share to Hypoxia-Inducible Factor 1

Share to Proto-Oncogene Proteins c-raf

Share to Shc Signaling Adaptor Proteins

Share to Src Homology 2 Domain-Containing, Transforming Protein 1

Share to Tyrphostins

Source

Identifiers

PMID: 12114320
DOI: 10.1161/01.res.0000024412.24491.ca

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Hypoxic induction of the hypoxia-inducible factor is mediated via the adaptor protein Shc in endothelial cells.PMID 12114320Read ↗

Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha.Semantic proximity Read ↗

The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration.Semantic proximity Read ↗

Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells.Semantic proximity Read ↗

Non-redundant role of Shc in Erk activation by cytoskeletal reorganization.Semantic proximity Read ↗

Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling.Semantic proximity Read ↗

TNFα signals via p66(Shc) to induce E-Selectin, promote leukocyte transmigration and enhance permeability in human endothelial cells.Semantic proximity Read ↗

Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia.Semantic proximity Read ↗

Src-dependent phosphorylation of the EGF receptor Tyr-845 mediates Stat-p21waf1 pathway in A431 cells.Semantic proximity Read ↗

The COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination.Semantic proximity Read ↗

Imatinib inhibits c-Kit-induced hypoxia-inducible factor-1alpha activity and vascular endothelial growth factor expression in small cell lung cancer cells.Semantic proximity Read ↗

Role of SHPS-1 in the regulation of insulin-like growth factor I-stimulated Shc and mitogen-activated protein kinase activation in vascular smooth muscle cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.