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Article

The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration.

The Journal of biological chemistry - 21 May 2004

Holmqvist Kristina, Cross Michael J, Rolny Charlotte, Hägerkvist Robert, Rahimi Nader, Matsumoto Taro, Claesson-Welsh Lena, Welsh Michael

Abstract excerpt

Previous studies have shown that the adaptor protein Shb is involved in receptor tyrosine kinase signaling. In this study, we demonstrate that Shb is phosphorylated in an Src-dependent manner upon vascular endothelial growth factor (VEGF) stimulation using porcine aortic endothelial cells expressing the human VEGF receptor 2 (VEGFR-2) (KDR). In co-immunoprecipitation experiments, we could detect an interaction...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Focal Adhesion Kinase 1

Share to Focal Adhesion Protein-Tyrosine Kinases

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Source

Identifiers

PMID: 15026417
DOI: 10.1074/jbc.M312729200

Genes

KDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration.PMID 15026417Read ↗

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