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Article

Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways.

Nature biotechnology - 1 Jan 2004

Parsons Ainslie B, Brost Renée L, Ding Huiming, Li Zhijian, Zhang Chaoying, Sheikh Bilal, Brown Grant W, Kane Patricia M, Hughes Timothy R, Boone Charles

Abstract excerpt

Bioactive compounds can be valuable research tools and drug leads, but it is often difficult to identify their mechanism of action or cellular target. Here we investigate the potential for integration of chemical-genetic and genetic interaction data to reveal information about the pathways and targets of inhibitory compounds. Taking advantage of the existing complete set of yeast haploid deletion mutants, we...

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PMID: 14661025
DOI: 10.1038/nbt919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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