Article
NetwoRx: connecting drugs to networks and phenotypes in Saccharomyces cerevisiae.
Nucleic acids research - 1 Jan 2013
Fortney Kristen, Xie Wing, Kotlyar Max, Griesman Joshua, Kotseruba Yulia, Jurisica Igor
Abstract excerpt
Drug modes of action are complex and still poorly understood. The set of known drug targets is widely acknowledged to be biased and incomplete, and so gives only limited insight into the system-wide effects of drugs. But a high-throughput assay unique to yeast-barcode-based chemogenomic screens-can measure the individual drug response of every yeast deletion mutant in parallel. NetwoRx...
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