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Cross‐species chemogenomic profiling reveals evolutionarily conserved drug mode of action

21 Dec 2010

Abstract excerpt

We present a cross-species chemogenomic screening platform using libraries of haploid deletion mutants from two yeast species, Saccharomyces cerevisiae and Schizosaccharomyces pombe. We screened a set of compounds of known and unknown mode of action (MoA) and derived quantitative drug scores (or D-scores), identifying mutants that are either sensitive or resistant to particular compounds. We found that...

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PMID: 21179023
DOI: 10.1038/msb.2010.107

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