Efficient strategies for screening large-scale genetic interaction networks

Abstract excerpt

Large-scale genetic interaction screening is a powerful approach for unbiased characterization of gene function and understanding systems-level cellular organization. While genome-wide screens are desirable as they provide the most comprehensive interaction profiles, they are resource and time-intensive and sometimes infeasible, depending on the species and experimental platform. For these scenarios, optimal metho...

Topics

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• Computational Biology
• Epistasis, Genetic
• Gene Expression Regulation, Neoplastic
• Gene Regulatory Networks
• Genes, Neoplasm
• Loss of Function Mutation
• Protein Interaction Maps
• Transcriptome

Identifiers and source

Literature Corpus work

7f97ea5c-57d3-5c79-b377-5ac03218e39c

DOI

10.1101/159632