Chemical-genetic approaches for exploring the mode of action of natural products.

doi:10.1007/978-3-7643-8595-8_5

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Article

Chemical-genetic approaches for exploring the mode of action of natural products.

Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques - 1 Jan 2008

Lopez Andres, Parsons Ainslie B, Nislow Corey, Giaever Guri, Boone Charles

Abstract excerpt

Determining the mode of action of bioactive compounds, including natural products, is a central problem in chemical biology. Because many genes are conserved from the yeast Saccharomyces cerevisiae to humans and a number of powerful genomics tools and methodologies have been developed for this model system, yeast is making a major contribution to the field of chemical genetics. The set of barcoded yeast deletion...

Topics

Animals
Antifungal Agents
Biological Products
Cluster Analysis
Drug Design
Gene Deletion
Gene Dosage
Gene Expression Regulation, Fungal
Gene Regulatory Networks
Genetic Engineering
Genomics
Humans
Metabolic Networks and Pathways
Mutation

Source

Open in PubMed

Identifiers

PMID: 18416308
DOI: 10.1007/978-3-7643-8595-8_5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Saccharomyces cerevisiae

Technology, Pharmaceutical