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Chemical-genetic approaches for exploring the mode of action of natural products.

Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques - 1 Jan 2008

Lopez Andres, Parsons Ainslie B, Nislow Corey, Giaever Guri, Boone Charles

Abstract excerpt

Determining the mode of action of bioactive compounds, including natural products, is a central problem in chemical biology. Because many genes are conserved from the yeast Saccharomyces cerevisiae to humans and a number of powerful genomics tools and methodologies have been developed for this model system, yeast is making a major contribution to the field of chemical genetics. The set of barcoded yeast deletion...

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PMID: 18416308
DOI: 10.1007/978-3-7643-8595-8_5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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