Functional Annotation of Chemical Libraries across Diverse Biological Processes

Abstract excerpt

Chemical-genetic approaches offer the potential for unbiased functional annotation of chemical libraries. Mutations can alter the response of cells to a compound, revealing chemical-genetic interactions that can elucidate a compound’s mode of action. We developed a highly parallel and unbiased yeast chemical-genetic screening system involving three key components. First, in a drug-sensitive genetic background, we...

Topics

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• Antifungal Agents
• Biological Products
• Drug Discovery
• Gene Regulatory Networks
• Genomics
• High-Throughput Nucleotide Sequencing
• Mutation
• Saccharomyces cerevisiae

Identifiers and source

Literature Corpus work

9fba5ad4-4cd7-51aa-b937-8ca1c0518bab

DOI

10.1101/112557