Article
Correlation of cytogenetic analysis and loss of heterozygosity studies in human diffuse astrocytomas and mixed oligo-astrocytomas.
Genes, chromosomes & cancer - 1 Nov 1992
Ransom D T, Ritland S R, Moertel C A, Dahl R J, O'Fallon J R, Scheithauer B W, Kimmel D W, Kelly P J, Olopade O I, Diaz M O
Abstract excerpt
The aims of this study were to correlate cytogenetic studies and molecular genetic loss of heterozygosity (LOH) analyses in human astrocytomas and mixed oligo-astrocytomas, and to locate putative tumor suppressor genes on chromosome 10. Paired blood and tumor samples from 53 patients were analyze...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Astrocytoma
- Brain Neoplasms
- Cell Transformation, Neoplastic
- Chromosome Aberrations
- Chromosomes, Human, Pair 10
- DNA Probes
- DNA, Neoplasm
- Female
- Genes, Tumor Suppressor
- Genetic Markers
- Humans