Allele loss on chromosomes 10 and 17p and epidermal growth factor receptor gene amplification in human malignant astrocytoma related to prognosis.

doi:10.1038/bjc.1994.373

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Article

Allele loss on chromosomes 10 and 17p and epidermal growth factor receptor gene amplification in human malignant astrocytoma related to prognosis.

British journal of cancer - 1 Oct 1994

Leenstra S, Bijlsma E K, Troost D, Oosting J, Westerveld A, Bosch D A, Hulsebos T J

Abstract excerpt

Patients with high-grade astrocytomas have a poor prognosis. However, considerable variation exists within this group of patients with respect to post-operative survival. In order to determine whether genetic alterations might be of help in subdividing this group, we used allele loss on chromosomes 10 and 17p and epidermal growth factor receptor (EGFR) gene amplification in the tumours as genetic parameters and...

Topics

Adult
Aged
Aging
Alleles
Astrocytoma
Brain Neoplasms
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 17
ErbB Receptors
Female
Gene Amplification

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Deletion

Heterozygote

Humans

Male

Middle Aged

Multivariate Analysis

Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 7917918
DOI: 10.1038/bjc.1994.373
PMCID: PMC2033395

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7917918-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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