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Article

p53 mutations are associated with 17p allelic loss in grade II and grade III astrocytoma.

Cancer research - 15 May 1992

von Deimling A, Eibl R H, Ohgaki H, Louis D N, von Ammon K, Petersen I, Kleihues P, Chung R Y, Wiestler O D, Seizinger B R

Abstract excerpt

Loss of genetic material on the short arm of chromosome 17 is observed in approximately 40% of human astrocytomas (WHO grades II and III) and in approximately 30% of cases of glioblastoma multiforme (WHO grade IV). Previous studies of glioblastoma multiforme have shown that the p53 gene, located on the short arm of chromosome 17, is frequently mutated in these glioblastomas. To explore whether lower-grade...

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PMID: 1349850

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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p53 mutations are associated with 17p allelic loss in grade II and grade III astrocytoma.PMID 1349850Read ↗

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p53 mutations in human malignant gliomas: comparison of loss of heterozygosity with mutation frequency.Semantic proximity Read ↗

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