Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 mutations are associated with 17p allelic loss in grade II and grade III astrocytoma.

Cancer research - 15 May 1992

von Deimling A, Eibl R H, Ohgaki H, Louis D N, von Ammon K, Petersen I, Kleihues P, Chung R Y, Wiestler O D, Seizinger B R

Abstract excerpt

Loss of genetic material on the short arm of chromosome 17 is observed in approximately 40% of human astrocytomas (WHO grades II and III) and in approximately 30% of cases of glioblastoma multiforme (WHO grade IV). Previous studies of glioblastoma multiforme have shown that the p53 gene, located on the short arm of chromosome 17, is frequently mutated in these glioblastomas. To explore whether lower-grade...

Topics

Alleles
Astrocytoma
Base Sequence
Blotting, Southern
Chromosome Deletion
Chromosomes, Human, Pair 17
DNA, Single-Stranded
Exons
Genes, p53
Heterozygote
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Nucleic Acid Conformation

Polymorphism, Genetic

Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 1349850

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1349850-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53 mutations are associated with 17p allelic loss in grade II and grade III astrocytoma.PMID 1349850Read ↗

Loss of heterozygosity on the short arm of chromosome 17 in human astrocytomas.Semantic proximity Read ↗

TP53 gene mutations and 17p deletions in human astrocytomas.Semantic proximity Read ↗

p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression.Semantic proximity Read ↗

Chromosome 17 allelic loss in astrocytic tumors and its clinico-pathologic implications.Semantic proximity Read ↗

p53 mutation, EGFR gene amplification and loss of heterozygosity on chromosome 10, 17 p in human gliomas.Semantic proximity Read ↗

Loss of heterozygosity on chromosome 10, 13q(Rb), 17p, and p53 gene mutations in human brain gliomas.Semantic proximity Read ↗

p53 mutations in human malignant gliomas: comparison of loss of heterozygosity with mutation frequency.Semantic proximity Read ↗

p53 expression in four human medulloblastoma-derived cell lines.Semantic proximity Read ↗

Pathways leading to glioblastoma multiforme: a molecular analysis of genetic alterations in 65 astrocytic tumors.Semantic proximity Read ↗

Deletions on the long arm of chromosome 17 in pilocytic astrocytoma.Semantic proximity Read ↗

Loss of heterozygosity of a locus on 17p13.3, independent of p53, is associated with higher grades of astrocytic tumoursSemantic proximity Read ↗

Chromosome 10 and 17 deletions and p53 gene mutations in Thai patients with astrocytomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.