Article
Loss of heterozygosity on chromosome 10, 13q(Rb), 17p, and p53 gene mutations in human brain gliomas.
Journal of Korean medical science - 1 Dec 1995
Lee S H, Kim J H, Rhee C H, Kang Y S, Lee J H, Hong S I, Choi K S
Abstract excerpt
Using the methods of restriction fragment length polymorphism (RFLP) and single strand conformation polymorphism (SSCP) analyses, we have examined 33 cases of human gliomas with various malignant grades to detect the deletions of putative tumor suppressor gene loci, chromosome 10, 13q(retinoblast...
Topics
- Astrocytoma
- Base Sequence
- Brain Neoplasms
- Chromosomes, Human, Pair 10
- Chromosomes, Human, Pair 13
- Chromosomes, Human, Pair 17
- Gene Deletion
- Genes, Retinoblastoma
- Genes, p53
- Glioma
- Heterozygote
- Humans
- Molecular Sequence Data
- Mutation
- Oligodendroglioma
- Polymorphism, Restriction Fragment Length
- Polymorphism, Single-Stranded Conformational