Article
Activity of hybrid type I interferons in cells lacking Tyk2: a common region of IFN-alpha 8 induces a response, but IFN-alpha2/8 hybrids can behave like IFN-beta.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Nov 2003
Platis Dimitris, Foster Graham R
Abstract excerpt
Type I interferons (IFNs) are a family of pleiotropic cytokines with antiviral, antiproliferative, and immunomodulatory properties. The type I IFN family consists of 12 IFN-alpha subtypes, IFN-beta, and IFN-omega. Cells lacking the receptor-associated protein kinase Tyk2 (U1A) are responsive only to IFN-beta and partially to IFN-alpha8. We constructed a series of IFN-alpha2/alpha8 hybrids and mutants and...
Topics
- Amino Acid Sequence
- Antibodies
- Cells, Cultured
- Humans
- Interferon-alpha
- Interferon-beta
- Molecular Sequence Data
- Mutation
- Protein-Tyrosine Kinases
- Receptor, Interferon alpha-beta
- Receptors, Interferon
- Sequence Alignment
- Sequence Homology, Amino Acid