Article
The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor.
Proceedings of the National Academy of Sciences of the United States of America - 28 Oct 1997
Gauzzi M C, Barbieri G, Richter M F, Uzé G, Ling L, Fellous M, Pellegrini S
Abstract excerpt
Tyk2 belongs to the Janus kinase (JAK) family of receptor associated tyrosine kinases, characterized by a large N-terminal region, a kinase-like domain and a tyrosine kinase domain. It was previously shown that Tyk2 contributes to interferon-alpha (IFN-alpha) signaling not only catalytically, but also as an essential intracellular component of the receptor complex, being required for high affinity binding of...
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