Article
Inquiring into the differential action of interferons (IFNs): an IFN-alpha2 mutant with enhanced affinity to IFNAR1 is functionally similar to IFN-beta.
Molecular and cellular biology - 1 Mar 2006
Jaitin Diego A, Roisman Laila C, Jaks Eva, Gavutis Martynas, Piehler Jacob, Van der Heyden Jose, Uze Gilles, Schreiber Gideon
Abstract excerpt
Alpha and beta interferons (IFN-alpha and IFN-beta) are multifunctional cytokines that exhibit differential activities through a common receptor composed of the subunits IFNAR1 and IFNAR2. Here we combined biophysical and functional studies to explore the mechanism that allows the alpha and beta IFNs to act differentially. For this purpose, we have engineered an IFN-alpha2 triple mutant termed the HEQ mutant that...
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