Article
TYK2 kinase activity is required for functional type I interferon responses in vivo.
PloS one - 1 Jan 2012
Prchal-Murphy Michaela, Semper Christian, Lassnig Caroline, Wallner Barbara, Gausterer Christian, Teppner-Klymiuk Ingeborg, Kobolak Julianna, Müller Simone, Kolbe Thomas, Karaghiosoff Marina, Dinnyés Andras, Rülicke Thomas, Leitner Nicole R, Strobl Birgit, Müller Mathias
Abstract excerpt
Tyrosine kinase 2 (TYK2) is a member of the Janus kinase (JAK) family and is involved in cytokine signalling. In vitro analyses suggest that TYK2 also has kinase-independent, i.e., non-canonical, functions. We have generated gene-targeted mice harbouring a mutation in the ATP-binding pocket of the kinase domain. The Tyk2 kinase-inactive (Tyk2(K923E)) mice are viable and show no gross abnormalities. We show that...
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