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Article

Induction of beta-R1/I-TAC by interferon-beta requires catalytically active TYK2.

The Journal of biological chemistry - 22 Jan 1999

Rani M R, Gauzzi C, Pellegrini S, Fish E N, Wei T, Ransohoff R M

Abstract excerpt

The beta-R1/I-TAC (interferon-inducible T-cell alpha-chemoattractant) gene encodes an alpha-chemokine that is a potent chemoattractant for activated T-cells. We previously reported that beta-R1 was selectively induced by interferon (IFN)-beta compared with IFN-alpha and that the canonical type I IFN transcription factor interferon-stimulated gene factor 3 (ISGF3) was necessary but not sufficient for beta-R1...

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Source

Identifiers

PMID: 9890942
DOI: 10.1074/jbc.274.4.1891

Genes

TYK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of beta-R1/I-TAC by interferon-beta requires catalytically active TYK2.PMID 9890942Read ↗

Characterization of β-R1, a Gene That Is Selectively Induced by Interferon β (IFN-β) Compared with IFN-αSemantic proximity Read ↗

Activity of hybrid type I interferons in cells lacking Tyk2: a common region of IFN-alpha 8 induces a response, but IFN-alpha2/8 hybrids can behave like IFN-beta.Semantic proximity Read ↗

The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor.Semantic proximity Read ↗

The Receptor Interaction Region of Tyk2 Contains a Motif Required for Its Nuclear LocalizationSemantic proximity Read ↗

Shared receptor components but distinct complexes for alpha and beta interferons.Semantic proximity Read ↗

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway.Semantic proximity Read ↗

The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression.Semantic proximity Read ↗

Cell-type-specific requirement for TYK2 in murine immune cells under steady state and challenged conditionsSemantic proximity Read ↗

Activation of the protein tyrosine kinase tyk2 by interferon alpha/beta.Semantic proximity Read ↗

The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction.Semantic proximity Read ↗

Differences in Activity between α and β Type I Interferons Explored by Mutational AnalysisSemantic proximity Read ↗

Tyrosine kinase 2 is not limiting human antiviral type III interferon responses.Semantic proximity Read ↗

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