Article
Induction of beta-R1/I-TAC by interferon-beta requires catalytically active TYK2.
The Journal of biological chemistry - 22 Jan 1999
Rani M R, Gauzzi C, Pellegrini S, Fish E N, Wei T, Ransohoff R M
Abstract excerpt
The beta-R1/I-TAC (interferon-inducible T-cell alpha-chemoattractant) gene encodes an alpha-chemokine that is a potent chemoattractant for activated T-cells. We previously reported that beta-R1 was selectively induced by interferon (IFN)-beta compared with IFN-alpha and that the canonical type I...
Topics
- Catalysis
- Chemokine CXCL11
- Chemokines, CXC
- Cloning, Molecular
- DNA
- Gene Expression Regulation
- Humans
- Interferon-beta
- Molecular Sequence Data
- Mutation
- Protein-Tyrosine Kinases
- Proteins