Article

Cell-type-specific requirement for TYK2 in murine immune cells under steady state and challenged conditions

2024-12-02

Abstract excerpt

<title>Abstract</title> <p>Tyrosine kinase 2 (TYK2) deficiency and loss or inhibition of kinase activity in men and mice leads to similar immune compromised phenotypes, predominantly through impairment of interferon (IFN) and interleukin 12 family responses. Here we relate the transcriptome changes to phenotypical changes observed in TYK2-deficient (Tyk2-/-) and TYK2 kinase-inactive (Tyk2K923E) mice in naïve sple...

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Literature Corpus work: 00d3ad93-f3eb-541f-af98-3814028203cc
DOI: 10.21203/rs.3.rs-5409693/v1

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